Refrigerator Perry is Inflamed by GBS

Former Chicago Bears defensive lineman William “The Refrigerator” Perry was admitted to a South Carolina hospital in serious condition with Guillain-Barre Syndrome. Perry was a 300-pound plus defensive tackle for the Chicago Bears’ 1985 Super Bowl team who became famous when coach Mike Ditka used him as a defensive fullback on goal-line plays. Perry crashed into the end zone for a touchdown in the Bears’ victory over the New England Patriots in the 1986 Super Bowl.

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Guillian-Barre Syndrome (GBS) is a disease where the body’s immune system turns against the nervous system. Specifically, the immune system attacks the coating around nerve cells (myelin) that allows them to transmit messages from the brain to the rest of the body.

It is unknown what causes GBS, but it is frequently preceded by a relatively mild viral illness, which in some way, may trigger the immune system to react in an abnormal way. Initial symptoms include muscle weakness and tingling in the legs. Weakness can progress up the body, and in severe cases, can cause complete paralysis. If the paralysis includes the breathing muscles, this is a medical emergency, and a patient must be put on a respirator.  Fortunately, the process is usually self-limited, and with support, the symptoms gradually resolve, although some mild weakness may remain.

Although there is no known cure for GBS, there are a couple of treatments that may lessen the symptoms or clear them up more quickly. One of these is called  plasmapheresis. The blood is removed from the body, filtered to remove harmful autoantibodies, and returned to the body).  The other is called high dose immunoglobulin therapy, where a patient receives an injection of  healthy antibodies pooled from a large number of donors. These antibodies block the harmful antibodies of GBS. However, the most critical part of treatment in all GBS patients is providing supportive care  to keep the body functioning during the illness.

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Mark Boguski, M.D., Ph.D. is on the faculty of Harvard Medical School and is a member of the Society for Participatory Medicine, "a movement in which networked patients shift from being mere passengers to responsible drivers of their health" and in which professional health care providers encourage "empowered patients" and value them as full partners in managing their health and wellness.

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