In the first 2013 episode of Oprah’s Next Chapter, Oprah sat down with Late Show host David Letterman.
The interview covered a variety of topics, including his sex scandal, his quintuple bypass heart surgery in 2000, and his alleged “feuds” with Jay Leno and Oprah herself.
He also spent some time talking about his struggles with depression, which he describes as a being in a “sinkhole.”
Letterman first acknowledged his diagnosis in 2010. Appearing on Live with Regis and Kelly, Letterman said the sex scandal surrounding his workplace affairs had triggered his depression.
Someone who is depressed has feelings of sadness or anxiety that last for weeks at a time. He or she may also experience:
Selective Serotonin Re-uptake Inhibitors (SSRIs) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. Some of the most commonly used ones include:
Neurotransmitters are chemicals that transmit signals from one nerve cell (neuron) to another across a gap called a synapse. The neurotransmitter is released from the first neuron (pre-synaptic neuron), travels across the gap and affects specific receptors on the next nerve cell thereby continuing the signal down the line. Common neurotransmitters include serotonin, dopamine, epinephrine, as well as others.
Serotonin, helps regulate sleep, appetite, and mood and inhibits pain.
In depression, the levels of serotonin in the synapse may be low, leading to the symptoms of the disease.
SSRI’s work by blocking the re-uptake transporter. This leaves more serotonin in the gap and improves the transmission across it.
The most common side effects associated with SSRIs include: